• Vaccine Name: Seasonal Influenza Vaccine -- Advax
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Type: trivalent human seasonal influenza vaccine (TIV)
• Status: Clinical trial
• Host Species for Licensed Use: Mouse
• Antigen: TIV (CSL): H1N1, H3N2, B; also inactivated PR8
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0005207
• Preparation: "Virus stocks were propagated in the allantoic fluid of 10- to 11-day-old fertile chicken eggs and purified by sucrose gradient ultracentrifugation as previously described [11] and stored at −80 °C until use. Advax™ adjuvant was combined with influenza antigen by simple admixture prior to immunization" (Honda-Okubo et al., 2012)
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Immune Response: Advax™ adjuvant increased neutralizing antibody and memory B-cell responses to influenza. It similarly enhanced CD4 and "CD8 T-cell proliferation and increased influenza-stimulated IL-2, IFN-γ, IL-5, IL-6, and GM-CSF responses. This translated into enhanced protection against mortality and morbidity in mice"