VIOLIN: Vaccine Investigation and Online Information Network

Vaccine Detail

ZF2001

Vaccine Information

Vaccine Name: ZF2001
Target Pathogen: SARS-CoV-2
Target Disease: COVID-19
Tradename: RBD-Dimer
Vaccine Ontology ID: VO_0005142
Type: Subunit vaccine
Status: Clinical trial
Host Species for Licensed Use: Human
Host Species as Laboratory Animal Model: Mouse
Immunization Route: Intramuscular injection (i.m.)
Description: A SARS-CoV-2 vaccine made of an SARS-CoV-2 RBD-sc-dimer (Dai et al., 2020)

Host Response

Mouse Response

Host Strain: Balb/c
Vaccination Protocol: Mice were immunized by subcutaneous injection with 50 μg of RBD-CuMVTT ((Zha, et al., 2020))
Immune Response: Induced neutralizing antibodies, production of RBD-Specific antibodies ((Zha, et al., 2020))

References

Dai et al., 2020: Dai L, Zheng T, Xu K, Han Y, Xu L, Huang E, An Y, Cheng Y, Li S, Liu M, Yang M, Li Y, Cheng H, Yuan Y, Zhang W, Ke C, Wong G, Qi J, Qin C, Yan J, Gao GF. A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS. Cell. 2020; 182(3); 722-733.e11. [PubMed: 32645327].

Zha, et al., 2020: Lisha Zha, Hongxin Zhao, Mona O. Mohsen, Liang Hong, Yuhang Zhou, Chuankai Yao, Lijie Guo, Zehua Li, Hongquan Chen, Xuelan Liu, Xinyue Chang, Jie Zhang, Dong Li, Ke Wu, Monique Vogel, Martin F Bachmann, Junfeng Wang. Development of a COVID-19 vaccine based on the receptor binding domain displayed on virus-like particles. . ; ; .