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Vaccine Detail
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VRP-MERS-N vaccine |
| Vaccine Information |
- Vaccine Name: VRP-MERS-N vaccine
- Target Pathogen: SARS-CoV
- Target Disease: Severe Acute Respiratory Syndrome (SARS)
- Type: Viral Like Particle Vaccine
- Status: Research
- Host Species for Licensed Use: None
- Host Species as Laboratory Animal Model: mouse
- Antigen: N protein (Zhao et al., 2016)
- Immunization Route: intranasal immunization
- Description: Venezuelan equine encephalitis replicons bearing epitopes of N protein from MERS(Zhao et al., 2016). Identical to VRP-MERS-N vaccine (Vaccine 5748).
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| Host Response |
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Mouse Response
- Host Strain: Balb/c (H-2d)
- Host age: 6 weeks (Zhao et al., 2016)
- Immune Response: Reduced viral titre, production of N-specific CD4+ T cells, Production of IFN-γ, Production of CD8+ T cells. (Zhao et al., 2016)
- Challenge Protocol: Mice were challenged 4-6 weeks after boosting (Zhao et al., 2016)
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| References |
Zhao et al., 2016: Zhao J, Zhao J, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S. Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity. 2016; 44(6); 1379-1391. [PubMed: 27287409].
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