• Vaccine Name: VRP-MERS-N vaccine
• Target Pathogen: MERS-CoV
• Target Disease: Middle East Respiratory Syndrome (MERS)
• Type: Viral Like Particle Vaccine
• Status: Research
• Host Species for Licensed Use: None
• Host Species as Laboratory Animal Model: mouse
• Antigen: N protein (Zhao et al., 2016)
• Immunization Route: intranasal immunization
• Description: Venezuelan equine encephalitis replicons bearing epitopes of N protein from MERS(Zhao et al., 2016).Identical to VRP-MERS-N vaccine (Vaccine 5754).

Mouse Response

• Host Strain: BALB/c
• Host age: 6 weeks (Zhao et al., 2016)
• Vaccination Protocol: BALB/c mice vaccinated at 2 μg/ml or 20 μg/ml and boosted with VRP-SARS-N, VRP-SARS-S, or VRP-GFP in the left footpad in 20 μL PBS or intranasally (i.n.) in 50 μL PBS after light anesthesia with isoflurane (Zhao et al., 2016)
• Immune Response: Reduced viral titre load, Production of N-specific CD4+ T cells, Production of IFN-γ, Production of CD8+ T cells. (Zhao et al., 2016)
• Challenge Protocol: Mice were challenged 4-6 weeks after boosting (Zhao et al., 2016)
• Efficacy: protected (Zhao et al., 2016)