• Vaccine Name: SARS-CoV Salmonella-tPA-S DNA vaccine
• Target Pathogen: SARS-CoV
• Target Disease: Severe Acute Respiratory Syndrome (SARS)
• Type: DNA vaccine
• Status: Research
• Host Species for Licensed Use: None
• Host Species as Laboratory Animal Model: mouse
• Antigen: S protein (Woo et al., 2005)
• S protein gene of SARS-CoV gene engineering:
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Oral
• Description: oral live-attenuated auxotrophic S. typhimurium aroA strain SL7207 that contained tPA-optimize800 DNA vaccine (Woo et al., 2005)

Mouse Response

• Host Strain: Balb/c (H-2d) (Woo et al., 2005)
• Host age: 6-8 weeks (Woo et al., 2005)
• Host gender: Male (Woo et al., 2005)
• Vaccination Protocol: oral injection of 6e9 live attenuated Salmonella typhimurium that underwent transfection of tPA-S (Woo et al., 2005)
• Immune Response: neutralizing antibody titers of <1:20–1:160, lymphocyte proliteration, production of IFN-γ, production of IL-4 (48hrs) (Woo et al., 2005)