• Vaccine Name: SARS-CoV CTLA4-S DNA vaccine
• Target Pathogen: SARS-CoV
• Target Disease: Severe Acute Respiratory Syndrome (SARS)
• Type: DNA vaccine
• Status: Research
• Host Species for Licensed Use: None
• Host Species as Laboratory Animal Model: mouse
• Antigen: S protein(Woo et al., 2005)
• S protein gene of SARS-CoV gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)
• Description: CTLA4HingeSARS800 DNA from SARS-CoV S protein vaccine (Woo et al., 2005)

Mouse Response

• Host Strain: Balb/c (H-2d) (Woo et al., 2005)
• Host age: 6-8 weeks (Woo et al., 2005)
• Host gender: Male (Woo et al., 2005)
• Vaccination Protocol: 100 μg intramuscular administration of vaccine, then 50 μg intraperitoneal injection at 14 and 28 days (Woo et al., 2005)
• Immune Response: Induced neutralizing antibody, high IgG levels, lymphocyte proliferation, production of IFN-γ, production of IL-4 (48hrs)
  (Woo et al., 2005)