• Vaccine Name: SARS-CoV tPA-S DNA vaccine
• Target Pathogen: SARS-CoV
• Target Disease: Severe Acute Respiratory Syndrome (SARS)
• Type: DNA vaccine
• Status: Research
• Host Species for Licensed Use: None
• Host Species as Laboratory Animal Model: mouse
• Antigen: S protein (Woo et al., 2005)
• S protein gene of SARS-CoV gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)
• Description: tPA-optimize800 DNA vaccine of SARS-CoV S protein (Woo et al., 2005)

Mouse Response

• Host Strain: Balb/c (H-2d) (Woo et al., 2005)
• Host age: 6-8 weeks (Woo et al., 2005)
• Host gender: Male (Woo et al., 2005)
• Vaccination Protocol: 100 μg of intramuscular administration of vaccine then 50 μg intraperitoneal injection of spike polypeptide at 28 and 42 days (Woo et al., 2005)
• Immune Response: neutralizing antibody titers of <1:20–1:160, lymphocyte proliteration, production of IFN-γ, production of IL-4 (48hrs) (Woo et al., 2005)