• Vaccine Name: SARS-CoV M protein DNA vaccine
• Target Pathogen: SARS-CoV
• Target Disease: Severe Acute Respiratory Syndrome (SARS)
• Type: DNA vaccine
• Status: Research
• Host Species for Licensed Use: None
• Host Species as Laboratory Animal Model: mouse
• Antigen: membrane protein (M) (Shi et al., 2006)
• membrane protein (M) gene of SARS-CoV gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)
• Description: DNA vaccine made from recombinant plasmid containing membrane protein (M) sequence constructed then expressed and purified from E. coli bacteria (Shi et al., 2006)

Mouse Response

• Host Strain: Balb/c (Shi et al., 2006)
• Vaccination Protocol: 20 μg of vaccine intramuscular injection (Shi et al., 2006)
• Immune Response: N-specific IgG (mostly IgG2a) (Shi et al., 2006)

Vole Response

• Host Strain: Microtus brandti raddes (Shi et al., 2006)
• Vaccination Protocol: 100 μg injected three times at an interval of 7 days (Shi et al., 2006)
• Immune Response: N-specific IgG (mostly IgG2a) (Shi et al., 2006)