|
|
Vaccine Detail
|
Ad5.MERS-S vaccine |
| Vaccine Information |
- Vaccine Name: Ad5.MERS-S vaccine
- Target Pathogen: MERS-CoV
- Target Disease: Middle East Respiratory Syndrome (MERS)
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Host Species as Laboratory Animal Model: mouse
- Antigen: S from MERS-CoV(Kim et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
- Description: Recombinant adenoviral vector encoding the full-length MERS-CoV S protein (Ad5.MERS-S) (Kim et al., 2014)
|
| Host Response |
|
Mouse Response
- Host Strain: BALB/C(Kim et al., 2014)
- Vaccination Protocol: inoculated intramuscularly with 1e11 viral particles of Vaccine 5719 and boosted intranasally 3 weeks after with 1e11 viral particles of Vaccine 5719
- Immune Response: increased titers of neutralizing antibodies, slightly higher specific response than Vaccine 5720 vaccine (Kim et al., 2014)
|
| References |
Kim et al., 2014: Kim E, Okada K, Kenniston T, Raj VS, AlHajri MM, Farag EA, AlHajri F, Osterhaus AD, Haagmans BL, Gambotto A. Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice. Vaccine. 2014; 32(45); 5975-5982. [PubMed: 25192975].
|
|
