• Vaccine Name: MERS England S1 subunit protein vaccine
• Target Pathogen: MERS-CoV
• Target Disease: Middle East Respiratory Syndrome (MERS)
• Type: Subunit vaccine
• Status: Research
• Host Species for Licensed Use: None
• Host Species as Laboratory Animal Model: mouse, rhesus monkey
• Antigen: S1 subunit of S from MERS-CoV. (Wang et al., 2015)
• Immunization Route: Intramuscular injection (i.m.)
• Description: A DNA vaccine constructed from a plasmid vaccines that encoded S1 subunit only. (Wang et al., 2015)

Mouse Response

• Host Strain: BALB/cJ (Wang et al., 2015)
• Host age: 6-8 weeks (Wang et al., 2015)
• Host gender: Female (Wang et al., 2015)
• Vaccination Protocol: immunized intramuscularly with plasmid DNA at weeks 0 3, and 6 (Wang et al., 2015)
• Immune Response: Induced high level of neutralizing antibodies (IgG1). (Wang et al., 2015)

Macaque Response

• Host Strain: Macaca mulatta (Wang et al., 2015)
• Host gender: Male and Female (Wang et al., 2015)
• Vaccination Protocol: Six NHPs in the protein-only group were injected with 100 μg of MERS-CoV S1 protein and AlPO4 adjuvant at weeks 0 and 8. (Wang et al., 2015)
• Immune Response: Induced high level of neutralizing antibodies (IgG1). Sera from immunized NHPs blocked mAbs targeted to the RBD and non-RBD S1 subunit, but not the S2 subunit. (Wang et al., 2015)
• Challenge Protocol: Animals were administered 100 μg of MERS-CoV S1 protein and AlPO4 adjuvant at weeks 0 and 8, then challenged with Jordan N3 strain of MERS-CoV 19 weeks after imunization at 3.1 x 10^6, 3.6 x 10^6, and 3.4 x 10^6 p.f.u. (Wang et al., 2015)
• Efficacy: protected (Wang et al., 2015)