VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
Host Responses
VaximmutorDB
VIGET
Vaxafe
Vaxar
Vaxism
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UM Logo

Vaccine Detail

MERS England1 S DNA vaccine
Vaccine Information
  • Vaccine Name: MERS England1 S DNA vaccine
  • Target Pathogen: MERS-CoV
  • Target Disease: Middle East Respiratory Syndrome (MERS)
  • Type: DNA vaccine
  • Status: Research
  • Host Species for Licensed Use: None
  • Host Species as Laboratory Animal Model: mouse, rhesus monkey
  • Antigen: S from MERS-CoV (Wang et al., 2015)
  • S from MERS-CoV gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: A DNA vaccine constructed from a plasmid vaccines that encoded full-length, membrane-anchored Spike protein. VRC8400 plasmid used to construct antigen (Wang et al., 2015)
Host Response

Mouse Response

  • Host Strain: BALB/cJ
  • Host age: 6-8 weeks (Wang et al., 2015)
  • Host gender: Female (Wang et al., 2015)
  • Vaccination Protocol: immunized with plasmid DNA at weeks 0, 3, and 6 (Wang et al., 2015)
  • Immune Response: high titers of neutralizing antibody (Wang et al., 2015)
References
Wang et al., 2015: Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman M, Vogel L, Johnson JC, Olinger G, Todd JP, Bagci U, Solomon J, Mollura DJ, Hensley L, Jahrling P, Denison MR, Rao SS, Subbarao K, Kwong PD, Mascola JR, Kong WP, Graham BS. Evaluation of candidate vaccine approaches for MERS-CoV. Nature communications. 2015; 6; 7712. [PubMed: 26218507].