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Vaccine Detail
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A. pleuropneumoniae HbpA vaccine |
| Vaccine Information |
- Vaccine Name: A. pleuropneumoniae HbpA vaccine
- Target Pathogen: Actinobacillus pleuropneumoniae
- Target Disease: porcine pleuropneumonia
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Host Species as Laboratory Animal Model: Pigs
- hbpA
gene engineering:
- Type: Recombinant protein preparation
- Description: he coding sequence of candidate genes were amplified from the genomic DNA of A. pleuropneumoniae JL03. The PCR products were cloned into pET28a and transformed into E. coli DH5α. Positive clones were transformed into E. coli BL21 (DE3) for expression. HbpA induced relatively higher levels of antibody titers compared with the other proteins, reaching 40% protection in mice when challenged with A. pleuropneumoniae JL03(Chen et al., 2012).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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| References |
Chen et al., 2012: Chen X, Xu Z, Li L, Chen H, Zhou R. Identification of conserved surface proteins as novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Journal of microbiology (Seoul, Korea). 2012; 50(6); 978-986. [PubMed: 23274984].
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