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Vaccine Detail

A. pleuropneumoniae TonB2 vaccine
Vaccine Information
  • Vaccine Name: A. pleuropneumoniae TonB2 vaccine
  • Target Pathogen: Actinobacillus pleuropneumoniae
  • Target Disease: porcine pleuropneumonia
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Host Species as Laboratory Animal Model: Mice
  • tonB2 gene engineering:
    • Type: Recombinant protein preparation
    • Description: The tonB2 gene was cloned from Actinobacillus pleuropneumoniae JL01 (serovar 1) and expressed as a glutathione-S-transferase (GST) fusion protein in Escherichia coli BL21(DE3). Purified soluble GST-TonB2 was assessed for its ability to protect BALB/c mice against A. pleuropneumoniae infection. Mice were vaccinated with GST-TonB2 subcutaneously and challenged intraperitoneally with either ~4.0 × 10^5 colony-forming units (CFU) or ~1.0 × 10^6 CFU of A. pleuropneumoniae 4074 (Liu et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: subcutaneous injection
Host Response
References
Liu et al., 2011: Liu J, Chen Y, Yuan F, Hu L, Bei W, Chen H. Cloning, expression, and characterization of TonB2 from Actinobacillus pleuropneumoniae and potential use as an antigenic vaccine candidate and diagnostic marker. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2011; 75(3); 183-190. [PubMed: 22210994].