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Vaccine Detail

ID93/GLA-SE
Vaccine Information
  • Vaccine Name: ID93/GLA-SE
  • Target Pathogen: Mycobacterium tuberculosis
  • Target Disease: Tuberculosis
  • Type: Subunit vaccine
  • Status: Clinical trial
  • Host Species for Licensed Use: Baboon
  • Rv1813c gene engineering:
    • Type: Recombinant protein preparation
    • Description: D93 was generated through a tandem fusion of the individual cloned and amplified genes of Rv3619, Rv1813, Rv3620, and Rv2608 using restriction site linkers.(Bertholet et al., 2010)
    • Detailed Gene Information: Click Here.
  • esxV gene engineering:
    • Type: Recombinant protein preparation
    • Description: ID93 was generated through a tandem fusion of the individual cloned and amplified genes of Rv3619, Rv1813, Rv3620, and Rv2608 using restriction site linkers.(Bertholet et al., 2010)
    • Detailed Gene Information: Click Here.
  • esxW gene engineering:
    • Type: Recombinant protein preparation
    • Description: ID93 was generated through a tandem fusion of the individual cloned and amplified genes of Rv3619, Rv1813, Rv3620, and Rv2608 using restriction site linkers.(Bertholet et al., 2010)
    • Detailed Gene Information: Click Here.
  • PPE42 gene engineering:
    • Type: Recombinant protein preparation
    • Description: ID93 was generated through a tandem fusion of the individual cloned and amplified genes of Rv3619, Rv1813, Rv3620, and Rv2608 using restriction site linkers.(Bertholet et al., 2010)
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response
References
Bertholet et al., 2010: Bertholet S, Ireton GC, Ordway DJ, Windish HP, Pine SO, Kahn M, Phan T, Orme IM, Vedvick TS, Baldwin SL, Coler RN, Reed SG. A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis. Science translational medicine. 2010; 2(53); 53ra74. [PubMed: 20944089].