|
|
Vaccine Detail
|
EspA-Tir-M novel fusion protein vaccine |
| Vaccine Information |
- Vaccine Name: EspA-Tir-M novel fusion protein vaccine
- Target Pathogen: Escherichia coli
- Target Disease: Hemorrhagic colitis
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: None
- Host Species as Laboratory Animal Model: Mouse
- Antigen: EspA-Tir-M (Lin et al., 2017).
- espA
gene engineering:
- Type: Recombinant protein preparation
- Description: (Lin et al., 2017)
- Detailed Gene Information: Click Here.
- Immunization Route: Nasal spray
- Description: Intranasal immunization with novel EspA-Tir-M fusion protein protected against EHEC O157:H7 colonization and infection in mice at a rate of 90%, and induced both humoral and cellular immune (Th1/Th2) responses in mice (Lin et al., 2017).
|
| Host Response |
|
|
| References |
Lin et al., 2017: Lin R, Zhu B, Zhang Y, Bai Y, Zhi F, Long B, Li Y, Wu Y, Wu X, Fan H. Intranasal immunization with novel EspA-Tir-M fusion protein induces protective immunity against enterohemorrhagic Escherichia coli O157:H7 challenge in mice. Microbial pathogenesis. 2017; 105; 19-24. [PubMed: 28163157].
|
|
