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Vaccine Detail
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Adenovirus 5-CD40 Ligand |
| Vaccine Information |
- Vaccine Name: Adenovirus 5-CD40 Ligand
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007200
- Type: Other
- Status: Research
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- CD40
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Description: An adenovirus vector engineered to produce CD40 ligand. For use as a possible gene therapy agent. May induce apoptosis through the TNF pathway which has been studied in preclinical stages (Loskog et al., 2004; NCIT_C2493).
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| Host Response |
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| References |
Loskog et al., 2004: Loskog A, Dzojic H, Vikman S, Ninalga C, Essand M, Korsgren O, Totterman TH. Adenovirus CD40 ligand gene therapy counteracts immune escape mechanisms in the tumor Microenvironment. Journal of immunology (Baltimore, Md. : 1950). 2004; 172(11); 7200-7205. [PubMed: 15153545].
NCIT_C2493: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2493]
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