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Vaccine Detail
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Vaccinia-GM-CSF Vaccine |
| Vaccine Information |
- Vaccine Name: Vaccinia-GM-CSF Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007121
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Csf2-Mouse
gene engineering:
- Preparation: A recombinant vaccinia virus is used as a vector expressing granulocyte-macrophage colony-stimulating factor (Qin and Chatterjee, 1996).
- Description: This is for Melanoma Cancer (NCT00002817). A recombinant vaccinia virus that encodes granulocyte-macrophage colony stimulating factor (GM-CSF). By activating T-cells and macrophages, vaccination with recombinant vaccinia GM-CSF may enhance the host immune system response to poorly immunogenic tumors, resulting in decreased tumor growth(NCI04) (Qin and Chatterjee, 1996; NCIT_C2674).
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| Host Response |
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| References |
NCIT_C2674: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2674]
NCT00002817: [https://clinicaltrials.gov/show/NCT00002817/]
Qin and Chatterjee, 1996: Qin H, Chatterjee SK. Cancer gene therapy using tumor cells infected with recombinant vaccinia virus expressing GM-CSF. Human gene therapy. 1996; 7(15); 1853-1860. [PubMed: 8894677].
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