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Vaccine Detail
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TRP1(0RF3):1-9 Peptide Vaccine |
| Vaccine Information |
- Vaccine Name: TRP1(0RF3):1-9 Peptide Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007116
- Type: Peptide vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- TRP-1
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Description: This is for Melanoma Cancer (NCT00019383). A recombinant peptide consisting of amino acid residues 1 to 9 of the tyrosinase-related protein 1 (TRP1). Expressed by cells of melanocyte origin, TRP1 is an enzyme involved in the process that converts tyrosinase to melanin pigments. Vaccination with TRP1(0RF3):1-9 may stimulate cytotoxic T cell responses to melanoma cells (NCI04) (Jiménez-Cervantes et al., 1994; NCIT_C2816).
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| Host Response |
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| References |
Jiménez-Cervantes et al., 1994: Jiménez-Cervantes C, Solano F, Kobayashi T, Urabe K, Hearing VJ, Lozano JA, García-Borrón JC. A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1). The Journal of biological chemistry. 1994; 269(27); 17993-18000. [PubMed: 8027058].
NCIT_C2816: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2816]
NCT00019383: [https://clinicaltrials.gov/show/NCT00019383/]
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