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Vaccine Detail
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Monoclonal Antibody GD2 Anti-Idiotype Vaccine |
| Vaccine Information |
- Vaccine Name: Monoclonal Antibody GD2 Anti-Idiotype Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007416
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- ST8SIA1
gene engineering:
- Type: Recombinant protein preparation
- Description: (Eger et al., 2016)
- Detailed Gene Information: Click Here.
- Description: An anti-idiotypic (anti-Id) rat monoclonal antibody (MoAb) that mimics the disialoganglioside GD2, a cancer-associated antigen present on melanoma, small cell lung cancer, sarcoma, neuroblastoma, and other malignancies. GD2 is a highly expressed glycosphingolipid by melanoma and other neuroectodermal tumors with only minimal expression on normal tissues. Vaccination with anti-Id A1G4 MoAb may elicit cellular and humoral immune responses against GD2 expression tumor cells. (NCIT_C26450).
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| Host Response |
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| References |
Eger et al., 2016: Eger C, Siebert N, Seidel D, Zumpe M, Jüttner M, Brandt S, Müller HP, Lode HN. Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma. PloS one. 2016; 11(3); e0150479. [PubMed: 26967324].
NCIT_C26450: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26450]
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