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Vaccine Detail
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Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes Vaccine |
| Vaccine Information |
- Vaccine Name: Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007268
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Antigen: p53
- human TP53 (P53)
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Preparation: α- and β-chain of a TCR from a highly avid murine CTL clone that recognized the human p53264–272 epitope were isolated and cloned into a retroviral vector that mediated high efficiency gene transfer into primary human lymphocytes (Cohen et al., 2005).
- Description: Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation. (NCIT_C64773).
Phase II trials involving metastatic cancers such as melanoma have used this vaccine. NCT00393029
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| Host Response |
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| References |
Cohen et al., 2005: Cohen CJ, Zheng Z, Bray R, Zhao Y, Sherman LA, Rosenberg SA, Morgan RA. Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR. Journal of immunology (Baltimore, Md. : 1950). 2005; 175(9); 5799-5808. [PubMed: 16237072].
NCIT_C64773: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C64773]
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