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Vaccine Detail
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NY-ESO-1b Peptide Vaccine |
| Vaccine Information |
- Vaccine Name: NY-ESO-1b Peptide Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007027
- Type: Peptide vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Antigen: NY-ESO-1
- CTAG1B
gene engineering:
- Type: Recombinant protein preparation
- Description: (Qiao et al., 2005)
- Detailed Gene Information: Click Here.
- Preparation: NY-ESO-1 specific CD8(+)T cells were in vitro induced by HLA-A2 Restricted NY-ESO-1b peptide (Qiao et al., 2005).
- Description: A recombinant nonapeptide used as an antineoplastic vaccine. NY-ESO-1b peptide vaccine contains the amino acid sequence SLLMWITQC, derived from the cancer-testis tumor antigen (NY-ESO-1), which is expressed on tumor cells of many different types, including melanomas. Vaccination with this peptide vaccine may elicit strong humoral and cellular immune responses to NY-ESO-1-expressing cancers (Shang et al., 2004; NCIT_C68999; NCT00199836) .
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| Host Response |
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| References |
NCIT_C68999: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68999]
NCT00199836: A Pilot Study of NY-ESO-1b Peptide Plus CpG 7909 and Montanide® ISA-51 in Patients With Cancer [https://clinicaltrials.gov/ct2/show/NCT00199836]
Qiao et al., 2005: Qiao H, Qian XP, Zhang HG, Tian C, Chen WF. [Estimation of an NY-ESO-1 expressing HCC cell line by NY-ESO-1b specific CD8+T cells in vitro induced by HLA-A2 restricted NY-ESO-1b peptide]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2005; 37(6); 565-568. [PubMed: 16378102].
Shang et al., 2004: Shang XY, Chen HS, Zhang HG, Pang XW, Qiao H, Peng JR, Qin LL, Fei R, Mei MH, Leng XS, Gnjatic S, Ritter G, Simpson AJ, Old LJ, Chen WF. The spontaneous CD8+ T-cell response to HLA-A2-restricted NY-ESO-1b peptide in hepatocellular carcinoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(20); 6946-6955. [PubMed: 15501973].
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