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Vaccine Detail
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Sialyl Tn-KLH Vaccine |
| Vaccine Information |
- Vaccine Name: Sialyl Tn-KLH Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007019
- Type: Other
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- sialyl-Tn
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Preparation: Theratope vaccine is a vaccine incorporating a synthetic STn antigen that emulates the carbohydrate seen on human tumors. It is administered subcutaneously at a dose of 100 µg of STn-KLH in phosphate-buffered saline (Holmberg and Sandmaier, 2001).
- Description: This is for Breast Cancer (NCT00003638). A vaccine containing a pancarcinoma carbohydrate antigen conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Sialylated Tn antigen (sTn) is a monosaccharide glycan usually O-linked to serine or threonine residues of mucins found on most epithelial cancers. Conjugation with KLH, a hapten carrier and an immunostimulant, improves host immune responses. Vaccination with sTn-KLH vaccine may produce antibodies and elicit a cytotoxic T lymphocyte (CTL) response against those tumor cells expressing sTn, resulting in decreased tumor growth (Ibrahim et al., 2013; NCIT_C1690).
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| Host Response |
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| References |
Holmberg and Sandmaier, 2001: Holmberg LA, Sandmaier BM. Theratope vaccine (STn-KLH). Expert opinion on biological therapy. 2001; 1(5); 881-891. [PubMed: 11728222].
Ibrahim et al., 2013: Ibrahim NK, Murray JL, Zhou D, Mittendorf EA, Sample D, Tautchin M, Miles D. Survival Advantage in Patients with Metastatic Breast Cancer Receiving Endocrine Therapy plus Sialyl Tn-KLH Vaccine: Post Hoc Analysis of a Large Randomized Trial. Journal of Cancer. 2013; 4(7); 577-584. [PubMed: 23983823].
NCIT_C1690: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1690]
NCT00003638: [https://clinicaltrials.gov/ct2/show/NCT00003638]
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