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Vaccine Detail
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Monoclonal Antibody A1G4 Anti-Idiotype Vaccine |
| Vaccine Information |
- Vaccine Name: Monoclonal Antibody A1G4 Anti-Idiotype Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007415
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- B4GALNT1
gene engineering:
- Type: Recombinant protein preparation
- Description: (Gajdosik, 2014)
- Detailed Gene Information: Click Here.
- Description: An anti-idiotypic (anti-Id) rat monoclonal antibody (MoAb) that mimics the disialoganglioside GD2, a cancer-associated antigen present on melanoma, small cell lung cancer, sarcoma, neuroblastoma, and other malignancies. GD2 is a highly expressed glycosphingolipid by melanoma and other neuroectodermal tumors with only minimal expression on normal tissues. Vaccination with anti-Id A1G4 MoAb may elicit cellular and humoral immune responses against GD2 expression tumor cells. (NCIT_C2436).
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| Host Response |
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| References |
Gajdosik, 2014: Gajdosik Z. Racotumomab - a novel anti-idiotype monoclonal antibody vaccine for the treatment of cancer. Drugs of today (Barcelona, Spain : 1998). 2014; 50(4); 301-307. [PubMed: 24918647].
NCIT_C2436: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2436]
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