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Vaccine Detail
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NY-ESO-1 Plasmid DNA Cancer Vaccine |
| Vaccine Information |
- Vaccine Name: NY-ESO-1 Plasmid DNA Cancer Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007025
- Type: DNA vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- CTAG1B
gene engineering:
- Preparation: The pDNA coding for NY-ESO-1 is loaded on 1.6 μm gold particles and cartridges holding the vaccine is delivered using Particle-Mediated Epidermal Delivery (Parvanova et al., 2011).
- Description: This is for Prostate Cancer, Bladder Cancer, Non-small Cell Lung Cancer, Esophageal Cancer and Sarcoma(NCT00199849). A plasmid DNA encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1 with potential immunostimulating and antitumor activities. Upon administration, NY-ESO-1 plasmid DNA cancer vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1 is a tumor associated antigen (TAA) found in normal testes and expressed on the surfaces of various tumor cells, including melanoma, breast, bladder, prostate, lung, ovarian, and hepatocellular tumor cells (Maraskovsky et al., 2004; Liu et al., 2011; NCIT_C62452).
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| Host Response |
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| References |
Liu et al., 2011: Liu Y, Tian X, Leitner WW, Aldridge ME, Zheng J, Yu Z, Restifo NP, Weiss R, Scheiblhofer S, Xie C, Sun R, Cheng G, Zeng G. Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo. The Journal of biological chemistry. 2011; 286(43); 37077-37084. [PubMed: 21900253].
Maraskovsky et al., 2004: Maraskovsky E, Sjölander S, Drane DP, Schnurr M, Le TT, Mateo L, Luft T, Masterman KA, Tai TY, Chen Q, Green S, Sjölander A, Pearse MJ, Lemonnier FA, Chen W, Cebon J, Suhrbier A. NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ t-cell-mediated immunity and protection against NY-ESO-1+ tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(8); 2879-2890. [PubMed: 15102697].
NCIT_C62452: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62452]
NCT00199849: NY-ESO-1 Plasmid DNA (pPJV7611) Cancer Vaccine [https://clinicaltrials.gov/ct2/show/NCT00199849]
Parvanova et al., 2011: Parvanova I, Rettig L, Knuth A, Pascolo S. The form of NY-ESO-1 antigen has an impact on the clinical efficacy of anti-tumor vaccination. Vaccine. 2011; 29(22); 3832-3836. [PubMed: 21470580].
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