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Vaccine Detail
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AFP Gene Hepatocellular Carcinoma Vaccine |
| Vaccine Information |
- Vaccine Name: AFP Gene Hepatocellular Carcinoma Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007213
- Type: Other
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- AFP
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Preparation: The vaccine is made using the mouse α-fetoprotein (AFP) gene in mouse hepatocellular carcinoma (HCC) cells (Saeki et al., 2004).
- Description: A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as a specific immunologic target for hepatocellular carcinoma. This agent exerts an antitumor effect by inducing cytotoxic T-lymphocytes to attack AFP-expressing tumor cells. (NCI04) (NCIT_C2512).
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| Host Response |
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| References |
NCIT_C2512: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2512]
Saeki et al., 2004: Saeki A, Nakao K, Nagayama Y, Yanagi K, Matsumoto K, Hayashi T, Ishikawa H, Hamasaki K, Ishii N, Eguchi K. Diverse efficacy of vaccination therapy using the alpha-fetoprotein gene against mouse hepatocellular carcinoma. International journal of molecular medicine. 2004; 13(1); 111-116. [PubMed: 14654980].
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