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Vaccine Detail

p53 Peptide Vaccine
Vaccine Information
  • Vaccine Name: p53 Peptide Vaccine
  • Target Pathogen: Cancer
  • Target Disease: Cancer
  • Vaccine Ontology ID: VO_0007030
  • Type: Peptide vaccine
  • Status: Clinical trial
  • Host Species for Licensed Use: Human
  • Host Species as Laboratory Animal Model: Human
  • Antigen: p53 (NCIT_C1986)
  • human TP53 (P53) gene engineering:
  • Preparation: Monocyte-derived DC were loaded with two modified HLA-class I p53 peptides (Schuler et al., 2014).
  • Description: This is for Breast Cancer and Ovarian Cancer(NCT00001827). A peptide-based cancer vaccine composed of amino acids 264 to 272 of the wild-type protein encoded by the P53 gene. p53 peptide vaccine may elicit an HLA-A2.1-restricted cytotoxic T lymphocyte immune response against tumor cells that overexpress p53 protein. (NCI04) (Schuler et al., 2014; NCIT_C1986).
Host Response
References
NCIT_C1986: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1986]
Schuler et al., 2014: Schuler PJ, Harasymczuk M, Visus C, Deleo A, Trivedi S, Lei Y, Argiris A, Gooding W, Butterfield LH, Whiteside TL, Ferris RL. Phase I dendritic cell p53 peptide vaccine for head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014; 20(9); 2433-2444. [PubMed: 24583792].