|
|
Vaccine Detail
|
Anti-idiotype MUC-1 Monoclonal Antibody Vaccine |
| Vaccine Information |
- Vaccine Name: Anti-idiotype MUC-1 Monoclonal Antibody Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007262
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- MUC1
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Preparation: Murine (m) (IgG1) and humanized (h) (IgG1) monoclonal anti-human MUC1 mAb were diluted in PBS with or without adjuvant in a final volume of 200 µl (Wilkinson et al., 2000).
- Description: A monoclonal antibody that functionally mimics MUC-1 antigen, a tumor cell surface antigen. Administration of anti-idiotype MUC-1 monoclonal antibody may elicit an anti-idiotype antibody and corresponding T-cell response against MUC-1 expressing tumor cells. (NCIT_C2709).
Phase I clinical trials involving various types in solid tumors that are MUC1-positive been reported. (de et al., 2004)
|
| Host Response |
|
|
| References |
de et al., 2004: de Bono JS, Rha SY, Stephenson J, Schultes BC, Monroe P, Eckhardt GS, Hammond LA, Whiteside TL, Nicodemus CF, Cermak JM, Rowinsky EK, Tolcher AW. Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity. Annals of oncology : official journal of the European Society for Medical Oncology. 2004; 15(12); 1825-1833. [PubMed: 15550589].
NCIT_C2709: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2709]
Wilkinson et al., 2000: Wilkinson RW, Ross EL, Lee-MacAry AE, Laylor R, Burchell J, Taylor-Papadimitriou J, Snary D. A transgenic mouse model for tumour immunotherapy: induction of an anti-idiotype response to human MUC1. British journal of cancer. 2000; 83(9); 1202-1208. [PubMed: 11027434].
|
|
