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Vaccine Detail
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IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051 |
| Vaccine Information |
- Vaccine Name: IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051
- Target Pathogen: Cancer
- Target Disease: Cancer
- Product Name: GS-501
- Vaccine Ontology ID: VO_0007438
- Type: Other
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Description: Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a modified form of the cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, IL-12-expressing MSC vaccine GX-051 secretes IL-12. IL-12 activates the immune system by both promoting the secretion of interferon-gamma, which activates natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in tumor cells. (NCIT_C114385).
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| Host Response |
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| References |
NCIT_C114385: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114385]
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