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Vaccine Detail
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Recombinant DNA-L523S Vaccine |
| Vaccine Information |
- Vaccine Name: Recombinant DNA-L523S Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007085
- Type: DNA vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- IGF2BP3
gene engineering:
- Type: Recombinant protein preparation
- Description: (Wang et al., 2003)
- Detailed Gene Information: Click Here.
- Preparation: Escherchia coli recombinant L523S protein was expressed in pPDM His, a modified pET28 vector (Wang et al., 2003).
- Description: This is for Lung Cancer (NCT00062907). A plasmid DNA encoding human L523S, an RNA-binding protein that belongs to the KOC (K homology domain containing protein overexpressed in cancer) family, with potential antineoplastic activity. Vaccination with L523S DNA may stimulate a cytotoxic T lymphocytes (CTL) response against tumor cells that express the L523S protein. As an oncofetal protein, L523S is normally expressed in early embryonic tissue, but is overexpressed in certain cancer cell types (NCIT_C49290).
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| Host Response |
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| References |
NCIT_C49290: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49290]
NCT00062907: [https://clinicaltrials.gov/show/NCT00062907]
Wang et al., 2003: Wang T, Fan L, Watanabe Y, McNeill PD, Moulton GG, Bangur C, Fanger GR, Okada M, Inoue Y, Persing DH, Reed SG. L523S, an RNA-binding protein as a potential therapeutic target for lung cancer. British journal of cancer. 2003; 88(6); 887-894. [PubMed: 12644826].
Wang et al., 2003: Wang XY, Chen X, Manjili MH, Repasky E, Henderson R, Subjeck JR. Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100. Cancer research. 2003; 63(10); 2553-2560. [PubMed: 12750279].
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