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Vaccine Detail

Autologous Dendritic Cell-Adenovirus P53 Vaccine

Vaccine Information

Vaccine Name: Autologous Dendritic Cell-Adenovirus P53 Vaccine
Target Pathogen: Cancer
Target Disease: Cancer
Vaccine Ontology ID: VO_0007285
Type: Recombinant vector vaccine
Status: Clinical trial
Host Species for Licensed Use: Human
Host Species as Laboratory Animal Model: Human
Antigen: p53
human TP53 (P53) gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
Preparation: DCs grown by culturing PBMC in the presence of GM-CSF and IL-4 were infected with an adenoviral construct containing wt-p53 (Chiappori et al., 2010).
Description: An autologous vaccine composed of dendritic cells (DC) that have been transduced with a p53 tumor suppressor gene-modified virus. When the autologous dendritic cell-adenovirus p53 vaccine is administered, the host cytotoxic T lymphocytes (CTL) are directed against p53-positive tumor cells, which may result in tumor cell death and decreased tumor growth. (NCI04) (NCIT_C26445).

This vaccine has been used used in clinical trials involving small cell lung cancer, metastatic solid tumors and invasive breast cancer. (Soliman et al., 2018; Chiappori et al., 2010)

Host Response

References

Chiappori et al., 2010: Chiappori AA, Soliman H, Janssen WE, Antonia SJ, Gabrilovich DI. INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert opinion on biological therapy. 2010; 10(6); 983-991. [PubMed: 20420527].

NCIT_C26445: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26445]

Soliman et al., 2018: Soliman H, Khambati F, Han HS, Ismail-Khan R, Bui MM, Sullivan DM, Antonia S. A phase-1/2 study of adenovirus-p53 transduced dendritic cell vaccine in combination with indoximod in metastatic solid tumors and invasive breast cancer. Oncotarget. 2018; 9(11); 10110-10117. [PubMed: 29515795].