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Vaccine Detail
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STn-KLH plus Detox Vaccine |
| Vaccine Information |
- Vaccine Name: STn-KLH plus Detox Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007020
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- sialyl-Tn
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Description: This is for Breast Cancer (NCT00003638). A vaccine comprised of a synthetic Sialyl-Tn antigen linked to the protein carrier, keyhole limpet hemocyanin (KLH), administered with immunostimulant, Detox. Vaccination with STn-KLH plus Detox may elicit an IgG-based anti-STn antibody response and ultimately a cytotoxic T-cell response against STn-expressing cancer cells (Longenecker et al., 1993; NCIT_C2501).
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| Host Response |
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| References |
Longenecker et al., 1993: Longenecker BM, Reddish M, Koganty R, MacLean GD. Immune responses of mice and human breast cancer patients following immunization with synthetic sialyl-Tn conjugated to KLH plus detox adjuvant. Annals of the New York Academy of Sciences. 1993; 690; 276-291. [PubMed: 7690215].
NCIT_C2501: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2501]
NCT00003638: [https://clinicaltrials.gov/ct2/show/NCT00003638]
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