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Vaccine Detail
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PSA RNA-Pulsed Dendritic Cell Vaccine |
| Vaccine Information |
- Vaccine Name: PSA RNA-Pulsed Dendritic Cell Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007150
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- KLK3
gene engineering:
- Type: Recombinant protein preparation
- Description: (Arlen et al., 2003)
- Detailed Gene Information: Click Here.
- Preparation: DCs were transfected with PSA RNA generated from the plasmid pGEM4/PSA/A64 (Heiser et al., 2002).
- Description: This is for Prostate Cancer (NCT00004211). An autologous dendritic cell vaccine with potential immunostimulatory activity. Dendritic cells harvested from a prostate cancer patient are transfected with the mRNA encoding for prostate specific antigen (PSA), a tumor marker secreted by prostatic epithelial and ductal cells. When reintroduced back to the patient, these PSA RNA pulsed autologous dendritic cells may elicit a cytotoxic T-cell (CTL) response against PSA-positive prostate cancer cells (Arlen et al., 2003; NCIT_C2236).
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| Host Response |
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| References |
Arlen et al., 2003: Arlen PM, Gulley JL, Palena C, Marshall J, Schlom J, Tsang KY. A novel ELISPOT assay to enhance detection of antigen-specific T cells employing antigen-presenting cells expressing vector-driven human B7-1. Journal of immunological methods. 2003; 279(1-2); 183-192. [PubMed: 12969559].
Arlen et al., 2003: Arlen PM, Gulley JL, Tsang KY, Schlom J. Strategies for the development of PSA-based vaccines for the treatment of advanced prostate cancer. Expert review of vaccines. 2003; 2(4); 483-493. [PubMed: 14711334].
Heiser et al., 2002: Heiser A, Coleman D, Dannull J, Yancey D, Maurice MA, Lallas CD, Dahm P, Niedzwiecki D, Gilboa E, Vieweg J. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. The Journal of clinical investigation. 2002; 109(3); 409-417. [PubMed: 11828001].
NCIT_C2236: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2236]
NCT00004211: [https://clinicaltrials.gov/ct2/show/NCT00004211]
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