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Vaccine Detail
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CVD 1208 |
| Vaccine Information |
- Vaccine Name: CVD 1208
- Target Pathogen: Shigella
- Target Disease: Shigellosis
- Vaccine Ontology ID: VO_0000666
- Type: Live, attenuated vaccine
- Status: Licensed
- Preparation: CVD 1208 is derived from wild type Shigella flexneri 2a strain 2457T and has defined deletions in four genes: (1) the guaBA chromosomal operon that encodes two enzymes (inositol 5'-monophosphate dehydrogenase and guanosine 5'synthase) essential for de novo purine biosynthesis; (2) set, a locus in a chromosomal pathogenicity island that encodes Shigella enterotoxin (ShET); (3) Pic, an autotransporter mucinase encoded on the opposite strand from set; and (4) sen, an invasiveness plasmid gene encoding ShET (Kotloff et al., 2004).
- Immunization Route: Intramuscular injection (i.m.)
- Virulence: Attenuated (Kotloff et al., 2004).
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| Host Response |
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| References |
Kotloff et al., 2004: Kotloff KL, Pasetti MF, Barry EM, Nataro JP, Wasserman SS, Sztein MB, Picking WD, Levine MM. Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208. The Journal of infectious diseases. 2004; 190(10); 1745-1754. [PubMed: 15499528].
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