• Vaccine Name: C-KCE (vBAC-C-KCE)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004812
• Type: Other
• Status: Licensed
• Host Species for Licensed Use: Baboon
• Immunization Route: Intramuscular injection (i.m.)

Ducks Response

• Vaccination Protocol: The attenuated DEV C-KCE vaccine strain, obtained from the China Institute of Veterinary Drugs Control, was propagated and titrated in primary chicken embryo fibroblasts (CEF) propagated in Eagle’s minimal essential medium (EMEM, Biochrom), which was supplemented with 100 μg/mL penicillin, 100 μg/mL streptomycin, and 10% fetal bovine serum (FBS) at 37 °C under a 5% CO2 atmosphere. A virulent DEV strain (HB/10) isolated from Hubei Province in the central part of China was propagated and titrated in duck embryo fibroblasts (DEF). AIV H5N1 A/duck/Hubei/xn/2007 (H5N1) (XN/07) (clade 2.3.2) (GenBank accession number of HA: AHI43271.1) and A/duck/Hubei/HangMei01/2006 (HM/06) (clade 2.3.4) (GenBank accession number of HA: ACF16400.1) were propagated in the allantoic cavities of 10-day-old specific-pathogen-free (SPF) embryonated chicken eggs and stored at −80 °C. (Zou et al., 2015)
• Immune Response: Ducks immunized with C-KCE-HA induced both the cross-reactive antibodies and T cell response against H5 (Zou et al., 2015).
• Efficacy: C-KCE-HA-immunized ducks provided rapid and long-lasting protection against homologous and heterologous HPAIV H5N1 and DEV clinical signs, death, and primary viral replication (Zou et al., 2015).
• Host IFNG from Macaca nemestrina response
  • Description: Vaccination with C-KCE induced upregulation of IFN-G in ducks T cells (Zou et al., 2015).
  • Detailed Gene Information: Click Here.