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Vaccine Detail
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M. bovis DNA vaccine pCI-Ag85B |
| Vaccine Information |
- Vaccine Name: M. bovis DNA vaccine pCI-Ag85B
- Target Pathogen: Mycobacterium bovis
- Target Disease: Tuberculosis
- Vaccine Ontology ID: VO_0004806
- Type: DNA vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Host Species as Laboratory Animal Model: Mouse
- 85-B
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine encoded Ag85B (Teixeira et al., 2006).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Efficacy: Ag85B DNA immunization induced a statistically significant reduction in M. bovis CFU numbers in spleens (log 0.56) compared to what was seen for mice that received the plasmid pCI alone (P < 0.05). However, there was no significant reduction in bacterial load in lungs of pCI-Ag85B-immunized mice compared to the pCI control group (Teixeira et al., 2006).
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| References |
Teixeira et al., 2006: Teixeira FM, Teixeira HC, Ferreira AP, Rodrigues MF, Azevedo V, Macedo GC, Oliveira SC. DNA vaccine using Mycobacterium bovis Ag85B antigen induces partial protection against experimental infection in BALB/c mice. Clinical and vaccine immunology : CVI. 2006; 13(8); 930-935. [PubMed: 16893994].
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