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Vaccine Detail

NYVAC-CSP (malaria)

Vaccine Information

Vaccine Name: NYVAC-CSP (malaria)
Target Pathogen: Plasmodium spp.
Target Disease: Malaria
Vaccine Ontology ID: VO_0004800
Type: Recombinant vector vaccine
Status: Research
Host Species for Licensed Use: Baboon
Host Species as Laboratory Animal Model: mouse
Vector:
- Vector name:
- VO vector ID: VO_0001093
Preparation: (Lanar et al., 1996) NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%).
Immunization Route: Intramuscular injection (i.m.)

Host Response

References

Lanar et al., 1996: Lanar DE, Tine JA, de Taisne C, Seguin MC, Cox WI, Winslow JP, Ware LA, Kauffman EB, Gordon D, Ballou WR, Paoletti E, Sadoff JC. Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria. Infection and immunity. 1996; 64(5); 1666-1671. [PubMed: 8613376].