• Vaccine Name: rVEE-HA(H1N1)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004784
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HA gene engineering:
  • Type: Recombinant vector construction
  • Description: The HA gene was transferred into the VEE vector (Davis et al., 1996).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001124
  • Description: (Davis et al., 1996)
• Preparation: (Davis et al., 1996) a VEE vector containing the complete influenza virus hemagglutinin (HA) gene of H1N1 influenza virus.
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized by subcutaneous inoculation of 10^4 PFU of vector without insert or HA vector in a 10-µl volume of diluent into each rear footpad (Davis et al., 1996).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Immunized mice were challenged intranasally with a virulent strain of influenza virus (Davis et al., 1996).
• Efficacy: For the immunized mice, replication of challenge virus in their lungs was restricted, and they were completely protected from signs of disease (Davis et al., 1996).