• Vaccine Name: NYVAC-PRV- gII/ gp50
• Target Pathogen: Pseudorabies virus
• Target Disease: Aujeszky's disease
• Vaccine Ontology ID: VO_0004778
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• GII gene engineering:
  • Type: Recombinant vector construction
  • Description: A NYVAC vaccinia vector containing genes for pseudorables virus glycoproteins gII and gp50 (Brockmeier and Mengeling, 1996).
  • Detailed Gene Information: Click Here.
• gp50 gene engineering:
  • Type: Recombinant vector construction
  • Description: A NYVAC vaccinia vector containing genes for pseudorables virus glycoproteins gII and gp50 (Brockmeier and Mengeling, 1996).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001093
  • Description: (Brockmeier and Mengeling, 1996)
• Preparation: (Brockmeier and Mengeling, 1996) A NYVAC vaccinia vector containing genes for PRV gII and gp50 .
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccination Protocol: The pigs were vaccinated via intramuscular injection in the thigh with 10^7 CCID50 of NYVAC/gp50 or NYVAC/gpII,gp50, 4 weeks apart (Brockmeier and Mengeling, 1996).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Vaccinated pigs were challenged with 10^8 PFU of Indiana-Funkhauser strain of PRV oronasally, 4 weeks after the second vaccination (Brockmeier and Mengeling, 1996).
• Efficacy: Both NYVAC vectors protected pigs similarly from virulent pseudorabies virus challenge (Brockmeier and Mengeling, 1996).