• Vaccine Name: NYVAC-Pf7
• Target Pathogen: Plasmodium falciparum
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001093
  • Description: (Ockenhouse et al., 1998)
• Preparation: NYVAC-Pf7, a highly attenuated vaccinia virus with 7 P. falciparum genes inserted into its genome (Ockenhouse et al., 1998).
• Immunization Route: Intramuscular injection (i.m.)

Human Response

• Vaccination Protocol: Volunteers were immunized with low-dose NYVAC-Pf7 intramuscularly in the deltoid region of alternate arms at 0, 4 and 26 weeks. Another group was immunized with a high-dose of NYVAC-Pf7 with the same schedule. A third control group was given saline solution at the same schedule of immunization (Ockenhouse et al., 1998).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Vaccinated volunteers were challenged with 5 P. falciparum infected mosquitoes (Ockenhouse et al., 1998).
• Efficacy: Of the 35 volunteers challenged with the bite of 5 P. falciparum-infected Anopheles mosquitoes, 1 was completely protected, and there was a significant delay in time to parasite patency in the groups of volunteers who received either the low or high dose of vaccine compared with control volunteers (Ockenhouse et al., 1998).