• Vaccine Name: ALVAC-JEV
• Target Pathogen: Japanese encephalitis virus
• Target Disease: Japanese encephalitis
• Vaccine Ontology ID: VO_0004777
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001128
  • Description: (Raengsakulrach et al., 1999)
• Preparation: Poxvirus-vectored vaccines for Japanese encephalitis (JE), NYVAC-JEV and ALVAC-JEV(Raengsakulrach et al., 1999).
• Immunization Route: Intramuscular injection (i.m.)

Monkey Response

• Vaccination Protocol: The vaccines were given to four monkeys each on study days 0 and 28 along with saline placebo on day 7. For controls, the licensed BIKEN JE vaccine and a saline placebo were given to other groups of four monkeys on days 0, 7, and 28 (Raengsakulrach et al., 1999).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Two months after the booster dose, all 16 monkeys were challenged intranasally with one 90% effective dose of JEV strain KE-93 (AP61-1, C6/36-1, Mm-1, SM-2) (Raengsakulrach et al., 1999).
• Efficacy: This study suggests that the NYVAC-JEV and ALVAC-JEV vaccines are safe and immunogenic in monkeys and that the NYVAC-JEV and BIKEN vaccines are effective in protecting monkeys from encephalitis (Raengsakulrach et al., 1999).