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Vaccine Detail
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NYVAC-EHV-1- vP1014 |
| Vaccine Information |
- Vaccine Name: NYVAC-EHV-1- vP1014
- Target Pathogen: Equid herpesvirus
- Target Disease: Equine Rhinopneumonitis
- Vaccine Ontology ID: VO_0004771
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: vP1014, a vaccinia-based construct (NYVAC) coding for the immediate early gene (gene 64) of EHV-1 (Paillot et al., 2006).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Horse Response
- Vaccination Protocol: EHV-primed yearling ponies expressing this haplotype were vaccinated once (n = 1), three (n = 1), or four times (n = 2), and one pony was kept as an unvaccinated control (Paillot et al., 2006).
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: The ponies were challenged with EHV-1 (Paillot et al., 2006).
- Efficacy: The results demonstrated that vaccination with a NYVAC-based construct coding for gene 64 stimulated CMI. This immune response alone did not protect against challenge infection. However, the study does illustrate that vaccinia-based vaccines can stimulate CMI in the horse and may therefore contribute to protection against disease caused by EHV-1 (Paillot et al., 2006).
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| References |
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