• Vaccine Name: rORFV-p40(Borna disease virus)
• Target Pathogen: Borna disease virus
• Vaccine Ontology ID: VO_0004769
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector: ORF virus vaccine vector
  • Vector name: ORF virus vaccine vector
  • VO vector ID: VO_0001108
  • Description: (Henkel et al., 2005)
• Preparation: The highly attenuated Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus (Henkel et al., 2005).
• Immunization Route: Intramuscular injection (i.m.)

Rat Response

• Vaccination Protocol: The rats were immunized at an age of 4 to 5 weeks in 2-week intervals by intramuscular application of D1701-VrVp40 (Henkel et al., 2005).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: 2 weeks after the last immunization 5 ×10^3 to 10 ×10^3 FFU of BDV were used for intracerebral challenge infection (Henkel et al., 2005).
• Efficacy: Rats immunized with D1701-VrVp40 exhibited protection against Borna Disease, and virus clearance from the infected brain was demonstrated in immunized animals. Even 4 and 8 months after the last immunization, all immunized animals were still protected against the disease (Henkel et al., 2005).