• Vaccine Name: rORFV-CSFV-E2
• Target Pathogen: Classical swine fever virus
• Target Disease: Classical swine fever, hog cholera
• Vaccine Ontology ID: VO_0004768
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• E2 gene engineering:
  • Type: Recombinant vector construction
  • Description: Using the new recombinant parapoxvirus (PPV) Orf virus (ORFV) as a vaccine expressing the CSFV E. (Voigt et al., 2007).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001108
  • Description: (Voigt et al., 2007)
• Preparation: (Voigt et al., 2007) the recombinant parapoxvirus (PPV) Orf virus (ORFV) as a vaccine expressing the CSFV E2 glycoprotein to protect CSFV chellange.
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccination Protocol: Pigs were vaccinated with ORFV (Voigt et al., 2007).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Pigs were challenged with CSFV (Voigt et al., 2007).
• Efficacy: Vector virus vaccinated swine were able to cope with the lymphocyte and in particular B-cell depression in peripheral blood after challenge showing no clinical signs and no viremia. Also, the vaccinated swine demonstrated that a single intra-muscular application confers solid protection (Voigt et al., 2007).