• Vaccine Name: rMVTT-HA-QH (H5N1)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004759
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001109
  • Description: (Xiao et al., 2013)
• Preparation: Using a replicating modified vaccinia virus Tian Tan strain (MVTT) as a vaccine vector, MVTTHA-QH and MVTTHA-AH were constructed, which expresses the H5 gene of a goose-derived Qinghai strain A/Bar-headed Goose/Qinghai/1/2005 or human-derived Anhui Strain A/Anhui/1/2005 (Xiao et al., 2013).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Groups of nine mice were either immunized with 1.5×10^6 or 3.0×10^6 PFU of MVTTHA-QH and MVTTS, respectively, twice, with a one month interval (Xiao et al., 2013).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: Immunized mice were challenged with either 100 MLD50 of A/BhG/QH/1/05 or 100 MLD50 of A/VN/1194/04 at 3 weeks post second immunization (Xiao et al., 2013).
• Efficacy: Mice vaccinated with intranasal MVTTHA-QH were completely protected from challenge with lethal dosages of A/Bar-headed Goose/Qinghai/1/2005 and the A/Viet Nam/1194/2004, respectively, but not control mice that received a mock MVTTS vaccine (Xiao et al., 2013).