• Vaccine Name: HVT-ILT(FC-126 strain)
• Target Pathogen: infectious laryngotracheitis virus
• Vaccine Ontology ID: VO_0004756
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector: herpesvirus of turkey vaccine vector
  • Vector name: herpesvirus of turkey vaccine vector
  • VO vector ID: VO_0001067
• Preparation: Turkey herpesvirus vector laryngotracheitis vaccine (HVT/LT) expressing the glycoprotein B gene of laryngotracheitis virus (LTV) (Esaki et al., 2013).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: The chickens were vaccinated with HVT/LT by the subcutaneous route at 1 day of age (Esaki et al., 2013).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: The vaccinated chickens were challenged with virulent LTV at 7 weeks of age (Esaki et al., 2013).
• Efficacy: The majority of the vaccinated chickens (92%-100%) were protected against challenge with virulent LTV. Efficacy of HVT/LT was further evaluated in broiler chickens from a commercial source after in ovo vaccination to embryos at 18 days of incubation. After challenge with virulent LTV at 21 and 35 days of age, 67% and 87% of HVT/LT-vaccinated chickens did not develop LT clinical signs, respectively, while 100% (21 days of age) and 73% (35 days of age) of the challenge control chickens showed clinical signs of LT (Esaki et al., 2013).