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Vaccine Detail
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rFPV-H5AI-L2 |
| Vaccine Information |
- Vaccine Name: rFPV-H5AI-L2
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004746
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: Recombinant fowlpox virus coexpressing the inserted HA and chiIL2 genes (rFPV-H5AIL2). (Yun et al., 2009).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccination Protocol: Chickens were divided into two groups and immunized with rFPV-HA or rFPV-H5AIL2 (Yun et al., 2009).
- Vaccine Immune Response Type: VO_0003057
- Efficacy: The group immunized with the rFPV-H5AIL2 exhibited the similar ratios of protective efficacy and virus shedding as the group immunized with the rFPV-HA in SPF chicken. However, in commercial chicken, the group immunized with the rFPV-H5AIL2 generated significantly higher protection against H5N1 avian influenza virus challenge and lower virus shedding than the group immunized with the rFPV-HA (Yun et al., 2009).
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| References |
Yun et al., 2009: Yun SL, Zhang W, Liu WJ, Zhang XR, Chen SJ, Wu YT, Peng DX, Liu XF. [Construction of recombinant fowlpox virus coexpressing HA gene from H5N1 avian influenza virus and chicken interleukin-2 gene and assessment of its protective efficacy]. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui]. 2009; 25(6); 430-436. [PubMed: 20077933].
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