• Vaccine Name: rFPV-AI-H5A-IL6
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004743
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector: fowlpox virus vaccine vector
  • Vector name: fowlpox virus vaccine vector
  • VO vector ID: VO_0001040
• Preparation: Recombinant fowlpox virus (rFPV-AIH5AIL6) coexpressing the haemagglutinin (HA) gene of the H5N1 subtype of the avian influenza virus (AIV) and chicken interleukin 6 gene (Qian et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Ducks Response

• Vaccination Protocol: The ducks were immunized subcutaneously with rFPV-SYHA, rFPV-AIH5AIL6, rFPV-IL6 and wt-FPV, respectively, at a titre of 105 PFU in a 0.2-ml inoculum (Qian et al., 2012).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Each duck was challenged with 0.2 ml of 105.75 EID50 of H5 AIV A/mallard/Huadong/SY/2005 by nose/eye drop (Qian et al., 2012).
• Efficacy: These animal studies demonstrated that rFPV-AIH5AIL6 induced a higher anti-AIV HI antibody response, an enhanced lymphocyte proliferation response, an elevated immune protection, and a reduction in virus shedding compared to a recombinant fowlpox virus expressing the HA gene alone (rFPV-SYHA) (Qian et al., 2012).