• Vaccine Name: ALVAC-MV-HA/F
• Target Pathogen: Measles virus
• Target Disease: Measles
• Vaccine Ontology ID: VO_0004741
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• F fusion protein gene engineering:
  • Type: Recombinant vector construction
  • Description: Canarypox virus (CPV) recombinants expressing the hemagglutinin (HA) and fusion (F) glycoproteins of measles virus (MV) (Taylor et al., 1992).
  • Detailed Gene Information: Click Here.
• H hemagglutinin protein gene engineering:
  • Type: Recombinant vector construction
  • Description: Canarypox virus (CPV) recombinants expressing the hemagglutinin (HA) and fusion (F) glycoproteins of measles virus (MV) (Taylor et al., 1992).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001128
• Preparation: Canarypox virus (CPV) recombinants expressing the hemagglutinin (HA) and fusion (F) glycoproteins of measles virus (MV) (Taylor et al., 1992).
• Immunization Route: Intramuscular injection (i.m.)

Dog Response

• Vaccination Protocol: Vaccinate the dogs with recombinant vaccine (Taylor et al., 1992).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Lethal does of canine distember virus (CDV) (Taylor et al., 1992).
• Efficacy: The recombinants elicited a protective immune response. The level of MV neutralizing antibodies and the level of protection induced against CDV challenge achieved by the host-restricted CPV vector were equivalent to that obtained by vaccinia virus vectors expressing the same MV antigens (Taylor et al., 1992).