• Vaccine Name: ALVAC-RV
• Target Pathogen: Rabies virus
• Target Disease: Rabies
• Vaccine Ontology ID: VO_0004728
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001128
• Preparation: A non-adjuvanted feline rabies vaccine developed using the canarypoxvirus vector (Jas et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Cat Response

• Vaccination Protocol: Seronegative cats were vaccinated at 12 weeks of age and received a booster vaccination one year later (Jas et al., 2012).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: The cats were challenged by inoculation of 1 mL of rabies virus in the neck muscles (0.5 mL on the left and right side of the spine). The inoculum was a homogenate of salivary glands of foxes and each cat received 10^7.7 mouse Lethal Dose 50, the equivalent of 10^6.8 CCID50.
• Efficacy: This vaccination regimen induced a strong and sustained antibody response, and all vaccinated animals were protected against virulent rabies challenge carried out 3 years after vaccination (Jas et al., 2012).