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Vaccine Detail
ALVAC-BTV-VP2/VP5 |
Vaccine Information |
- Vaccine Name: ALVAC-BTV-VP2/VP5
- Target Pathogen: Bluetongue virus
- Target Disease: Bluetongue disesase
- Vaccine Ontology ID: VO_0004726
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: A recombinant canarypox virus vector was used to co-express genes encoding the VP2 and VP5 outer capsid proteins of bluetongue virus (Boone et al., 2007).
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Sheep Response
- Vaccine Immune Response Type: VO_0000287
- Challenge Protocol: The field strain of BTV-17 was used for challenging (Boone et al., 2007).
- Efficacy: The sheep vaccinated with the recombinant canarypox virus vectored vaccine were resistant to challenge with a field strain of BTV-17 (Boone et al., 2007).
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References |
Boone et al., 2007: Boone JD, Balasuriya UB, Karaca K, Audonnet JC, Yao J, He L, Nordgren R, Monaco F, Savini G, Gardner IA, Maclachlan NJ. Recombinant canarypox virus vaccine co-expressing genes encoding the VP2 and VP5 outer capsid proteins of bluetongue virus induces high level protection in sheep. Vaccine. 2007; 25(4); 672-678. [PubMed: 17059856].
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